Diet‐induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism
Excessive uptake of fatty acids and glucose by adipose tissue triggers adipocyte dysfunction
and infiltration of immune cells. Altered metabolic homeostasis in adipose tissue promotes
insulin resistance, type 2 diabetes, hypertension, and cardiovascular disease. Inflammatory
and metabolic processes are mediated by certain proteolytic enzymes that share a common
cellular target, protease‐activated receptor 2 (PAR2). This study showed that human and rat
obesity correlated in vivo with increased expression of PAR2 in adipose tissue, primarily in …
and infiltration of immune cells. Altered metabolic homeostasis in adipose tissue promotes
insulin resistance, type 2 diabetes, hypertension, and cardiovascular disease. Inflammatory
and metabolic processes are mediated by certain proteolytic enzymes that share a common
cellular target, protease‐activated receptor 2 (PAR2). This study showed that human and rat
obesity correlated in vivo with increased expression of PAR2 in adipose tissue, primarily in …
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